POLG

Across TCGA pan-cancer cohorts, POLG mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated POLG data layer compared with 24 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher POLG mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated POLG expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, LUAD, and LSCC are the cancer types where POLG mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.937	0.535	.002	8	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	7	view →
LSCC	OS	Quartile	II,III,IV	0.913	0.602	.037	2	view →
PDAC	DFS	Tertile	II,III,IV	0.684	0.828	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

POLG–CCRCC (DFS)

Open the CCRCC breakdown →