POLG

Across TCGA patient cohorts, POLG protein abundance is significantly associated with the RNA expression of many other genes, with 6,532 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible POLG-associated genes across cancer lineages are MYC, SEC24D, and BGN. Each is linked with POLG in more than 3 cancer types. Because this analysis shows association rather than direction, both POLG-to-partner and partner-to-POLG results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLG versus MYC in BRCA, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLG→partner) and Y-score (partner→POLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MYC →	+1.012	+0.228	.001	<.001	3	3
OV	SEC24D →	-0.653	-0.213	.001	.002	3	3
OV	BGN →	-1.695	-0.241	.003	.001	3	3
LSCC	LINC01711 →	-0.686	-0.213	.001	<.001	3	3
LUAD	BTN3A3 →	-0.603	-0.170	<.001	<.001	3	3
LSCC	XAF1 →	-0.664	-0.156	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,532 associations by consensus.

POLG vs MYC — BRCA

Explore this scatter interactively →