POLG

Across TCGA patient cohorts, POLG mutation is significantly associated with the RNA expression of many other genes, with 1,948 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLG-associated genes across cancer lineages are COX15, CENPU, and TYW3. Each is linked with POLG in more than 2 cancer types. Because this analysis shows association rather than direction, both POLG-to-partner and partner-to-POLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX15 grouped by POLG-low versus POLG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLG→partner) and Y-score (partner→POLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COX15 →	+0.331	+2.423	.003	.001	3	3
UCEC	CENPU →	+0.481	+1.999	.008	.002	3	3
UCEC	TYW3 →	+0.409	+2.458	<.001	.001	3	3
UCEC	FXN →	+0.320	+1.654	.004	.002	3	3
COAD	FUT10 →	+0.473	+3.222	.004	.008	3	3
UCEC	CTDNEP1 →	+0.250	+3.186	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,948 associations by consensus.

COX15 by POLG expression — UCEC

Explore this box plot interactively →