POLG

Across TCGA patient cohorts, POLG mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLG-associated genes across cancer lineages are eEF2, EGFR_pY1068, and Caspase-7-cleavedD198. Each is linked with POLG in more than 1 cancer types. Because this analysis shows association rather than direction, both POLG-to-partner and partner-to-POLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by POLG-low versus POLG-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLG→partner) and Y-score (partner→POLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eEF2 →	+0.475	+3.178	.001	.010	3	2
COAD	EGFR_pY1068 →	-0.378	-3.000	.019	.034	3	2
COAD	Caspase-7-cleavedD198 →	+1.025	+2.824	.008	.034	3	2
COAD	4E-BP1 →	+0.224	+3.178	.038	.010	3	2
UCEC	4E-BP1_pT37_T46 →	-0.326	-1.700	.015	.042	3	2
UCEC	c-Jun_pS73 →	-0.114	-3.156	.046	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

eEF2 by POLG expression — COAD

Explore this box plot interactively →