POLG

Across TCGA cell cohorts, POLG RNA expression is significantly associated with the go_rna of many other GO terms, with 4,352 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POLG-associated GO terms across cancer lineages are DNA replication proofreading, Positive regulation of DNA-templated DNA replication, and Signal transduction in response to DNA damage. Each is linked with POLG in more than 16 cancer types. Because this analysis shows association rather than direction, both POLG-to-partner and partner-to-POLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication proofreading grouped by POLG-low versus POLG-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLG→partner) and Y-score (partner→POLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DNA replication proofreading →	+0.189	+0.955	<.001	<.001	3	17
BONE	Positive regulation of DNA-templated DNA replication →	+0.153	+0.856	<.001	<.001	3	15
BONE	Signal transduction in response to DNA damage →	+0.065	+0.742	.002	.003	2	15
URINARY_TRACT	Telomere maintenance →	+0.059	+0.750	.005	.006	3	14
SOFT_TISSUE	Telomere organization →	+0.058	+0.842	<.001	<.001	3	14
BLOOD_Leukemia	Positive regulation of nuclear cell cycle DNA replication →	+0.136	+0.839	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,352 associations by consensus.

DNA replication proofreading by POLG expression — SOFT_TISSUE

Explore this box plot interactively →