POLG

Across TCGA cell cohorts, POLG mutation is significantly associated with the RNA expression of many other genes, with 214 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POLG-associated genes across cancer lineages are SERPINB4, OR1N1, and OR2T29. Each is linked with POLG in more than 1 cancer types. Because this analysis shows association rather than direction, both POLG-to-partner and partner-to-POLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SERPINB4 grouped by POLG-low versus POLG-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLG→partner) and Y-score (partner→POLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SERPINB4 →	+0.325	+2.624	.005	.003	3	2
SOFT_TISSUE	OR1N1 →	+0.032	+5.369	<.001	.004	3	1
OESOPHAGUS	OR2T29 →	+0.116	+4.906	<.001	.006	3	1
URINARY_TRACT	CRYGC →	+0.200	+5.087	<.001	.004	3	1
URINARY_TRACT	TSPY2 →	+0.256	+5.087	<.001	.004	3	1
BLOOD_Leukemia	PHOX2B →	+0.016	+4.365	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 214 associations by consensus.

SERPINB4 by POLG expression — LARGE_INTESTINE

Explore this box plot interactively →