POLG

Across TCGA cell cohorts, POLG mutation is significantly associated with the mutation status of many other genes, with 5,046 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POLG-associated genes across cancer lineages are HIF1A, ARFGEF2, and WDR7. Each is linked with POLG in more than 5 cancer types. Because this analysis shows association rather than direction, both POLG-to-partner and partner-to-POLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HIF1A grouped by POLG-low versus POLG-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLG→partner) and Y-score (partner→POLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	HIF1A →	+4.584	+4.584	.007	.007	1	6
BLOOD_Lymphoma	ARFGEF2 →	+3.584	+4.922	.001	.001	1	6
STOMACH	WDR7 →	+4.807	+4.807	.008	.008	1	5
BLOOD_Lymphoma	ZNF496 →	+4.584	+4.584	.007	.007	1	5
LARGE_INTESTINE	DENND4A →	+1.906	+2.865	<.001	<.001	1	5
UPPER_AERODIGESTIVE_TRACT	PRRC2A →	+4.392	+4.954	.008	.008	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,046 associations by consensus.

HIF1A by POLG expression — BLOOD_Lymphoma

Explore this box plot interactively →