POLE4

Across TCGA pan-cancer cohorts, POLE4 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of POLE4’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where POLE4 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types POLE4 is over-expressed in tumor, although a few such as PDAC and COAD show the opposite, repressed pattern.

LUAD, LSCC, and CCRCC are the cancer types where POLE4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLE4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	+0.631	<.001	9	view →
LSCC	Male	II,III,IV	+0.700	<.001	8	view →
CCRCC	Male	All	+0.413	<.001	6	view →
PDAC	Female	All	−0.441	.021	3	view →
OV	All	All	+0.858	.002	2	view →
COAD	Male	III,IV	−0.444	.014	2	view →
HNSC	Male	IV	+0.237	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

POLE4–LUAD

Open the LUAD breakdown →