POLE3

Across TCGA patient cohorts, POLE3 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,464 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible POLE3-associated proteins across cancer lineages are SMC2, POLE4, and SMC4. Each is linked with POLE3 in more than 8 cancer types. Because this analysis shows association rather than direction, both POLE3-to-partner and partner-to-POLE3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLE3 versus SMC2 in LSCC, with a Pearson correlation of 0.73.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (POLE3→partner) and Y-score (partner→POLE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SMC2 →	+0.687	+0.668	<.001	<.001	3	9
OV	POLE4 →	+0.566	+0.689	<.001	<.001	3	8
GBM	SMC4 →	+0.724	+0.391	<.001	<.001	3	8
LSCC	MCM2 →	+0.619	+0.637	<.001	<.001	3	8
LSCC	MCM3 →	+0.683	+0.584	<.001	<.001	3	8
GBM	MCM4 →	+0.702	+0.377	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,464 associations by consensus.

POLE3 vs SMC2 — LSCC

Explore this scatter interactively →