POLE

Across TCGA patient cohorts, POLE protein abundance is significantly associated with the RNA expression of many other genes, with 11,848 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible POLE-associated genes across cancer lineages are TOP2A, CDKN3, and OIP5. Each is linked with POLE in more than 6 cancer types. Because this analysis shows association rather than direction, both POLE-to-partner and partner-to-POLE results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLE versus TOP2A in HNSC, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLE→partner) and Y-score (partner→POLE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TOP2A →	+1.432	+0.465	<.001	<.001	3	7
UCEC	CDKN3 →	+1.009	+0.581	<.001	<.001	3	6
UCEC	OIP5 →	+0.709	+0.607	<.001	<.001	3	6
HNSC	KIF20A →	+1.332	+0.319	<.001	<.001	3	6
GBM	ECT2 →	+0.755	+0.470	<.001	.002	3	6
BRCA	CENPL →	+0.785	+0.387	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,848 associations by consensus.

POLE vs TOP2A — HNSC

Explore this scatter interactively →