POLE

Across TCGA cell cohorts, POLE mutation is significantly associated with the RNA expression of many other genes, with 981 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POLE-associated genes across cancer lineages are TPBGL, IL3, and OR2C3. Each is linked with POLE in more than 2 cancer types. Because this analysis shows association rather than direction, both POLE-to-partner and partner-to-POLE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TPBGL grouped by POLE-low versus POLE-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLE→partner) and Y-score (partner→POLE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TPBGL →	+0.284	+3.495	<.001	.005	3	3
URINARY_TRACT	IL3 →	+0.020	+4.087	<.001	.009	3	2
URINARY_TRACT	OR2C3 →	+0.022	+4.087	<.001	.009	3	2
BLOOD_Leukemia	FAM149A →	+0.708	+3.303	.006	.004	3	2
BLOOD_Leukemia	HBS1L →	+0.764	+3.321	.002	.005	3	2
BLOOD_Leukemia	OTX1 →	+0.883	+3.489	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 981 associations by consensus.

TPBGL by POLE expression — CNS

Explore this box plot interactively →