POLDIP3

Across TCGA patient cohorts, POLDIP3 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLDIP3-associated genes across cancer lineages are ATM, 14-3-3_beta, and eEF2. Each is linked with POLDIP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both POLDIP3-to-partner and partner-to-POLDIP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by POLDIP3-low versus POLDIP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLDIP3→partner) and Y-score (partner→POLDIP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.676	-2.906	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.109	-3.143	.010	.018	3	1
UCEC	eEF2 →	+0.382	+1.700	.011	.044	3	1
UCEC	eIF4E →	+0.239	+4.000	.007	<.001	3	1
UCEC	FoxM1 →	+0.310	+2.222	.004	.011	3	1
UCEC	FOXO3a_pS318_S321 →	-0.113	-2.449	.032	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

ATM by POLDIP3 expression — UCEC

Explore this box plot interactively →