POLDIP3

Across TCGA pan-cancer cohorts, POLDIP3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of POLDIP3’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where POLDIP3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POLDIP3 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

LIHC, THCA, and LUAD are the cancer types where POLDIP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLDIP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	III,IV	+1.126	<.001	9	view →
THCA	All	II,III,IV	−0.488	<.001	9	view →
LUAD	Male	All	−0.405	<.001	8	view →
HNSC	All	All	+0.373	<.001	6	view →
CHOL	All	II,III,IV	+2.524	<.001	5	view →
KICH	All	All	−0.634	<.001	5	view →
UCEC	All	All	−0.826	<.001	4	view →
STAD	Male	II,III,IV	+0.572	.010	4	view →
BRCA	Female	II,III,IV	−0.228	.006	4	view →
KIRP	All	All	−0.317	.010	2	view →
KIRC	Male	II,III,IV	−0.258	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

POLDIP3–LIHC

Open the LIHC breakdown →