POLDIP3

Across TCGA cell cohorts, POLDIP3 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POLDIP3-associated genes across cancer lineages are TMCO5A, BHMT, and LRIT1. Each is linked with POLDIP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both POLDIP3-to-partner and partner-to-POLDIP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMCO5A grouped by POLDIP3-low versus POLDIP3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLDIP3→partner) and Y-score (partner→POLDIP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMCO5A →	+0.019	+4.415	<.001	.007	3	1
BLOOD_Leukemia	BHMT →	+0.213	+3.745	<.001	.005	3	1
BLOOD_Leukemia	LRIT1 →	+0.030	+3.684	<.001	.004	3	1
BLOOD_Leukemia	C16orf92 →	+0.171	+4.359	<.001	<.001	3	1
BLOOD_Leukemia	OR10K1 →	+0.337	+3.234	.006	.008	3	1
BLOOD_Leukemia	SFT2D3 →	+0.525	+3.450	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

TMCO5A by POLDIP3 expression — LARGE_INTESTINE

Explore this box plot interactively →