POLDIP2

Across TCGA patient cohorts, POLDIP2 mutation is significantly associated with the RNA expression of many other genes, with 108 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLDIP2-associated genes across cancer lineages are RNU6-629P, IFNG, and KLRD1. Each is linked with POLDIP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both POLDIP2-to-partner and partner-to-POLDIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-629P grouped by POLDIP2-low versus POLDIP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLDIP2→partner) and Y-score (partner→POLDIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-629P →	+0.255	+4.137	<.001	<.001	3	2
UCEC	IFNG →	+1.014	+3.384	<.001	.004	3	1
UCEC	KLRD1 →	+0.361	+3.459	.005	.005	3	1
UCEC	TRIM29 →	-1.518	-3.459	.001	.005	3	1
BLCA	OR11J5P →	+0.059	+7.640	<.001	.009	3	1
UCEC	RN7SL134P →	+0.148	+3.114	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 108 associations by consensus.

RNU6-629P by POLDIP2 expression — UCEC

Explore this box plot interactively →