POLDIP2

Across TCGA pan-cancer cohorts, POLDIP2 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of POLDIP2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where POLDIP2 RNA is repressed in tumor relative to normal tissue. In most cancer types POLDIP2 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, BLCA, and HNSC are the cancer types where POLDIP2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLDIP2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.229	<.001	10	view →
BLCA	Female	All	+0.733	<.001	10	view →
HNSC	All	IV	+0.391	<.001	10	view →
LUAD	Male	III,IV	+0.746	<.001	9	view →
LIHC	Male	All	+0.597	<.001	9	view →
COAD	Female	II,III,IV	+0.477	<.001	9	view →
KIRC	Male	II,III,IV	−0.479	<.001	7	view →
THCA	Male	III,IV	−0.388	<.001	7	view →
LUSC	Female	All	+0.992	<.001	6	view →
BRCA	All	III,IV	+0.481	<.001	6	view →
UCEC	All	All	+0.446	.005	6	view →
STAD	Male	II,III,IV	+0.716	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

POLDIP2–KICH

Open the KICH breakdown →