POLDIP2

Across TCGA patient cohorts, POLDIP2 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLDIP2-associated genes across cancer lineages are p38-MAPK_pT180_Y182, PDCD4, and Rb_pS807_S811. Each is linked with POLDIP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both POLDIP2-to-partner and partner-to-POLDIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by POLDIP2-low versus POLDIP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLDIP2→partner) and Y-score (partner→POLDIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.559	-2.986	.031	.037	3	1
UCEC	PDCD4 →	-0.886	-3.000	.001	.037	3	1
UCEC	Rb_pS807_S811 →	-0.521	-3.000	.026	.037	3	1
UCEC	CDK1 →	+0.188	+3.000	.031	.037	3	1
UCEC	c-Met_pY1235 →	+0.116	+3.000	.006	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

p38-MAPK_pT180_Y182 by POLDIP2 expression — UCEC

Explore this box plot interactively →