POLA2

Across TCGA patient cohorts, POLA2 protein abundance is significantly associated with the RNA expression of many other genes, with 7,280 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible POLA2-associated genes across cancer lineages are CENPI, NCAPG, and HJURP. Each is linked with POLA2 in more than 6 cancer types. Because this analysis shows association rather than direction, both POLA2-to-partner and partner-to-POLA2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLA2 versus CENPI in UCEC, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLA2→partner) and Y-score (partner→POLA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPI →	+1.088	+0.691	<.001	<.001	3	7
UCEC	NCAPG →	+1.319	+0.607	<.001	.005	3	7
UCEC	HJURP →	+1.602	+0.572	<.001	.005	3	7
UCEC	KIF2C →	+1.381	+0.512	.001	.003	3	7
OV	WDHD1 →	+1.126	+0.683	<.001	.003	2	7
GBM	CHEK1 →	+1.161	+1.059	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,280 associations by consensus.

POLA2 vs CENPI — UCEC

Explore this scatter interactively →