POLA2

Across TCGA patient cohorts, POLA2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLA2-associated genes across cancer lineages are FOXO3a, Collagen-VI, and FoxM1. Each is linked with POLA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both POLA2-to-partner and partner-to-POLA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a grouped by POLA2-low versus POLA2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLA2→partner) and Y-score (partner→POLA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	FOXO3a →	-0.109	-2.982	.032	.034	3	2
BLCA	Collagen-VI →	-0.303	-2.982	.032	.034	3	2
UCEC	FoxM1 →	+0.298	+2.087	.002	.005	3	2
UCEC	GAPDH →	+0.414	+1.874	.044	.049	3	2
UCEC	Notch1 →	+0.183	+2.013	<.001	.016	3	2
UCEC	ATM →	-0.748	-3.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

FOXO3a by POLA2 expression — BLCA

Explore this box plot interactively →