POLA2

Across TCGA cell cohorts, POLA2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,971 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POLA2-associated GO terms across cancer lineages are Mitotic cell cycle checkpoint signaling, DNA replication, and DNA-templated DNA replication. Each is linked with POLA2 in more than 19 cancer types. Because this analysis shows association rather than direction, both POLA2-to-partner and partner-to-POLA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic cell cycle checkpoint signaling grouped by POLA2-low versus POLA2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLA2→partner) and Y-score (partner→POLA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Mitotic cell cycle checkpoint signaling →	+0.118	+1.407	.008	<.001	3	20
BONE	DNA replication →	+0.148	+1.510	<.001	<.001	3	20
BONE	DNA-templated DNA replication →	+0.134	+1.236	<.001	<.001	3	20
PANCREAS	DNA strand elongation involved in DNA replication →	+0.208	+1.306	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication maintenance of fidelity →	+0.098	+1.130	<.001	<.001	3	20
OVARY	Spindle elongation →	+0.260	+0.918	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,971 associations by consensus.

Mitotic cell cycle checkpoint signaling by POLA2 expression — BONE

Explore this box plot interactively →