POLA1

Across TCGA patient cohorts, POLA1 mutation is significantly associated with the RNA expression of many other genes, with 4,624 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLA1-associated genes across cancer lineages are RMC1, CCDC43, and PRC1. Each is linked with POLA1 in more than 3 cancer types. Because this analysis shows association rather than direction, both POLA1-to-partner and partner-to-POLA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RMC1 grouped by POLA1-low versus POLA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLA1→partner) and Y-score (partner→POLA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RMC1 →	+0.258	+1.295	<.001	<.001	3	4
UCEC	CCDC43 →	+0.393	+1.194	<.001	<.001	3	3
UCEC	PRC1 →	+0.527	+1.567	<.001	<.001	3	3
UCEC	RNU2-27P →	+0.552	+1.726	<.001	<.001	3	3
LUAD	KANK1P1 →	+0.150	+2.050	<.001	.009	3	3
READ	PINCR →	+0.181	+4.142	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,624 associations by consensus.

RMC1 by POLA1 expression — UCEC

Explore this box plot interactively →