PODN

Across TCGA patient cohorts, PODN mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PODN-associated genes across cancer lineages are eEF2, GAPDH, and INPP4B. Each is linked with PODN in more than 2 cancer types. Because this analysis shows association rather than direction, both PODN-to-partner and partner-to-PODN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PODN-low versus PODN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PODN→partner) and Y-score (partner→PODN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.275	+1.502	.017	.027	3	3
UCEC	GAPDH →	+0.452	+1.906	.009	.014	3	3
COAD	INPP4B →	-0.578	-3.313	<.001	.010	3	2
UCEC	NF2 →	+0.201	+1.906	.004	.014	3	2
UCEC	PCNA →	+0.290	+2.736	<.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.295	-1.999	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

eEF2 by PODN expression — UCEC

Explore this box plot interactively →