PODN

Across TCGA cell cohorts, PODN mutation is significantly associated with the RNA expression of many other genes, with 153 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PODN-associated genes across cancer lineages are MYF5, GCAT, and ZMYND8. Each is linked with PODN in more than 1 cancer types. Because this analysis shows association rather than direction, both PODN-to-partner and partner-to-PODN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYF5 grouped by PODN-low versus PODN-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PODN→partner) and Y-score (partner→PODN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MYF5 →	+0.023	+5.169	<.001	.005	3	1
LARGE_INTESTINE	GCAT →	+1.226	+2.628	<.001	.002	3	1
LARGE_INTESTINE	ZMYND8 →	-0.820	-2.541	<.001	.005	3	1
LARGE_INTESTINE	BMF →	-0.873	-2.541	.007	.005	3	1
LARGE_INTESTINE	IL27RA →	+0.859	+2.628	.005	.002	3	1
LARGE_INTESTINE	PMP22 →	+1.747	+3.743	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 153 associations by consensus.

MYF5 by PODN expression — BREAST

Explore this box plot interactively →