POC1B

Across TCGA pan-cancer cohorts, POC1B Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated POC1B data layer compared with 30 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher POC1B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated POC1B expression acts as an unfavorable survival marker.

LUAD, BRCA, and COAD are the cancer types where POC1B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.307	0.834	.001	15	view →
BRCA	DFS	Median	All	0.644	0.902	.029	14	view →
COAD	OS	Median	All	0.172	0.870	<.001	12	view →
UCEC	OS	Median	IV	0.100	0.781	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

POC1B–LUAD (OS)

Open the LUAD breakdown →