POC1B

Across TCGA pan-cancer cohorts, POC1B RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of POC1B’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where POC1B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POC1B is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

LIHC, COAD, and KICH are the cancer types where POC1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POC1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	All	+0.500	<.001	9	view →
COAD	Male	All	+0.870	<.001	8	view →
KICH	Female	All	−1.066	<.001	7	view →
READ	All	II,III,IV	+0.717	.006	6	view →
BRCA	All	II,III,IV	+0.298	<.001	6	view →
CHOL	Male	All	+2.085	<.001	5	view →
STAD	Male	All	+0.737	<.001	5	view →
LUAD	All	All	+0.356	<.001	4	view →
UCEC	All	III,IV	+0.873	.027	2	view →
LUSC	All	III,IV	−0.495	.005	2	view →
ESCA	All	All	+0.870	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

POC1B–LIHC

Open the LIHC breakdown →