POC1B

Across TCGA pan-cancer cohorts, POC1B mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated POC1B data layer compared with 30 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher POC1B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated POC1B expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, UCEC, and GBM are the cancer types where POC1B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	IV	0.961	0.183	.017	8	view →
UCEC	OS	Tertile	All	0.844	0.973	.034	4	view →
GBM	OS	Median	All	0.601	0.417	.045	1	view →
LSCC	DFS	Quartile	III,IV	0.832	0.474	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

POC1B–CCRCC (DFS)

Open the CCRCC breakdown →