POC1B-GALNT4

Across TCGA patient cohorts, POC1B-GALNT4 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POC1B-GALNT4-associated genes across cancer lineages are Caspase-8, JNK2, and MEK1. Each is linked with POC1B-GALNT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both POC1B-GALNT4-to-partner and partner-to-POC1B-GALNT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by POC1B-GALNT4-low versus POC1B-GALNT4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POC1B-GALNT4→partner) and Y-score (partner→POC1B-GALNT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.268	-2.558	.008	.010	3	2
UCEC	JNK2 →	+0.253	+1.901	.001	.028	3	1
UCEC	MEK1 →	+0.471	+3.321	.001	.009	3	1
UCEC	p62 Lck ligand →	+0.308	+2.415	.018	.003	3	1
UCEC	PCNA →	+0.207	+1.906	.017	.016	3	1
UCEC	PDK1_pS241 →	+0.202	+2.115	.003	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Caspase-8 by POC1B-GALNT4 expression — UCEC

Explore this box plot interactively →