POC1B-AS1

Across TCGA pan-cancer cohorts, POC1B-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of POC1B-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where POC1B-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POC1B-AS1 is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

COAD, THCA, and LIHC are the cancer types where POC1B-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POC1B-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	+0.525	<.001	10	view →
THCA	Female	II,III,IV	−0.380	<.001	9	view →
LIHC	All	All	+0.130	<.001	8	view →
BLCA	Female	III,IV	+0.344	.016	4	view →
STAD	All	All	+0.241	.003	4	view →
CHOL	Male	All	+0.853	<.001	3	view →
READ	All	All	+0.375	.001	2	view →
LUSC	All	III,IV	−0.293	.006	2	view →
BRCA	Female	All	−0.160	.031	2	view →
KIRP	All	II,III,IV	+0.278	.041	1	view →
KICH	All	All	−0.204	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

POC1B-AS1–COAD

Open the COAD breakdown →