PNPT1

Across TCGA pan-cancer cohorts, PNPT1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PNPT1 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PNPT1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PNPT1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

PDAC, LSCC, and CCRCC are the cancer types where PNPT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	II,III,IV	0.759	0.946	.001	27	view →
LSCC	DFS	Quartile	II,III,IV	0.939	0.462	.003	22	view →
CCRCC	DFS	Tertile	II,III,IV	0.377	0.847	.001	15	view →
GBM	OS	Quartile	All	1.000	0.888	.029	7	view →
LUAD	OS	Quartile	All	0.550	0.889	.005	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PNPT1–PDAC (OS)

Open the PDAC breakdown →