PNPT1

Across TCGA patient cohorts, PNPT1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNPT1-associated genes across cancer lineages are TFRC, CDK1, and EGFR_pY1068. Each is linked with PNPT1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PNPT1-to-partner and partner-to-PNPT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by PNPT1-low versus PNPT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPT1→partner) and Y-score (partner→PNPT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.636	+2.000	.002	.010	3	4
UCEC	CDK1 →	+0.153	+3.183	.010	.009	3	3
UCEC	EGFR_pY1068 →	-0.234	-2.000	.017	.030	3	2
UCEC	FoxM1 →	+0.209	+2.179	.039	.034	3	2
UCEC	4E-BP1 →	+0.312	+2.489	.003	.010	3	2
UCEC	Cyclin-B1 →	+0.666	+3.459	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

TFRC by PNPT1 expression — UCEC

Explore this box plot interactively →