PNPT1

Across TCGA cell cohorts, PNPT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,611 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PNPT1-associated GO terms across cancer lineages are Mitochondrial mRNA polyadenylation, Regulation of mitochondrial RNA catabolic process, and Positive regulation of mitochondrial RNA catabolic process. Each is linked with PNPT1 in more than 19 cancer types. Because this analysis shows association rather than direction, both PNPT1-to-partner and partner-to-PNPT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial mRNA polyadenylation grouped by PNPT1-low versus PNPT1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPT1→partner) and Y-score (partner→PNPT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Mitochondrial mRNA polyadenylation →	+0.195	+1.237	<.001	<.001	3	20
KIDNEY	Regulation of mitochondrial RNA catabolic process →	+0.150	+1.598	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mitochondrial RNA catabolic process →	+0.182	+1.357	<.001	<.001	3	18
PANCREAS	Mitochondrial mRNA catabolic process →	+0.118	+1.007	.001	<.001	3	17
LARGE_INTESTINE	Transcription by RNA polymerase I →	+0.108	+0.867	<.001	<.001	3	16
BLOOD_Lymphoma	Transcription initiation at RNA polymerase I promoter →	+0.125	+1.429	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,611 associations by consensus.

Mitochondrial mRNA polyadenylation by PNPT1 expression — STOMACH

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