PNPO

Across TCGA patient cohorts, PNPO mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNPO-associated genes across cancer lineages are MEK1, Annexin_VII, and BRCA2. Each is linked with PNPO in more than 1 cancer types. Because this analysis shows association rather than direction, both PNPO-to-partner and partner-to-PNPO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by PNPO-low versus PNPO-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPO→partner) and Y-score (partner→PNPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.417	+3.000	.048	.036	3	1
UCEC	Annexin_VII →	-0.175	-3.000	.029	.037	3	1
UCEC	BRCA2 →	-0.165	-2.992	.024	.036	3	1
UCEC	14-3-3_beta →	-0.125	-2.986	.032	.037	2	1
UCEC	eEF2 →	+0.434	+3.000	.035	.037	2	1
UCEC	PDCD4 →	-0.659	-3.000	.015	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MEK1 by PNPO expression — UCEC

Explore this box plot interactively →