PNPLA8

Across TCGA patient cohorts, PNPLA8 RNA expression is significantly associated with the RNA expression of many other genes, with 19,729 significant associations in total. UVM shows the largest number of these associations.

The most reproducible PNPLA8-associated genes across cancer lineages are STIM1, ESYT2, and SRPK2. Each is linked with PNPLA8 in more than 33 cancer types. Because this analysis shows association rather than direction, both PNPLA8-to-partner and partner-to-PNPLA8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PNPLA8 versus STIM1 in ACC, with a Pearson correlation of 0.60.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA8→partner) and Y-score (partner→PNPLA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	STIM1 →	+1.200	+1.311	<.001	<.001	3	34
UVM	ESYT2 →	+1.315	+1.537	<.001	<.001	3	34
UVM	SRPK2 →	+1.370	+1.589	<.001	<.001	3	33
CHOL	CAPRIN1 →	+1.166	+0.851	<.001	.001	3	33
UVM	CAB39 →	+1.413	+1.650	<.001	<.001	3	33
UVM	EPC2 →	+1.467	+1.658	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,729 associations by consensus.

PNPLA8 vs STIM1 — ACC

Explore this scatter interactively →