PNPLA8

Across TCGA patient cohorts, PNPLA8 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,875 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PNPLA8-associated proteins across cancer lineages are TIMM8A_S96, ZKSCAN1, and PHF11_S17. Each is linked with PNPLA8 in more than 3 cancer types. Because this analysis shows association rather than direction, both PNPLA8-to-partner and partner-to-PNPLA8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PNPLA8 versus TIMM8A_S96 in PDAC, with a Pearson correlation of -0.42.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA8→partner) and Y-score (partner→PNPLA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TIMM8A_S96 →	-0.713	-0.255	<.001	<.001	3	4
HNSC	ZKSCAN1 →	+0.390	+0.559	<.001	.001	3	3
BRCA	PHF11_S17 →	-0.548	-0.638	.007	<.001	3	3
BRCA	CLTB →	+0.322	+0.682	.002	.001	3	3
CCRCC	MPLKIP_S133 →	+0.389	+0.252	.001	.002	3	3
PDAC	SEC13 →	-0.174	-0.319	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,875 associations by consensus.

PNPLA8 vs TIMM8A_S96 — PDAC

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