PNPLA8

Across TCGA cell cohorts, PNPLA8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,634 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PNPLA8-associated GO terms across cancer lineages are Enzyme-directed rRNA pseudouridine synthesis, Vesicle budding from membrane, and Macroautophagy. Each is linked with PNPLA8 in more than 15 cancer types. Because this analysis shows association rather than direction, both PNPLA8-to-partner and partner-to-PNPLA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Enzyme-directed rRNA pseudouridine synthesis grouped by PNPLA8-low versus PNPLA8-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA8→partner) and Y-score (partner→PNPLA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Enzyme-directed rRNA pseudouridine synthesis →	-0.145	-0.847	<.001	<.001	3	16
OVARY	Vesicle budding from membrane →	+0.081	+0.972	<.001	<.001	3	13
SKIN	Macroautophagy →	+0.043	+0.725	<.001	<.001	3	13
BLOOD_Myeloma	Autophagosome assembly →	+0.069	+0.932	<.001	<.001	3	12
PANCREAS	Golgi vesicle transport →	+0.065	+0.980	.003	.001	3	12
SKIN	Process utilizing autophagic mechanism →	+0.042	+0.589	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,634 associations by consensus.

Enzyme-directed rRNA pseudouridine synthesis by PNPLA8 expression — LUNG_SCLC

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