PNPLA8

Across TCGA cell cohorts, PNPLA8 mutation is significantly associated with the RNA expression of many other genes, with 337 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PNPLA8-associated genes across cancer lineages are GFRAL, OR4A47, and DMRTB1. Each is linked with PNPLA8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PNPLA8-to-partner and partner-to-PNPLA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRAL grouped by PNPLA8-low versus PNPLA8-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA8→partner) and Y-score (partner→PNPLA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GFRAL →	+0.028	+4.684	<.001	<.001	3	2
LUNG_NSCLC_LUAD	OR4A47 →	+0.016	+3.813	<.001	.001	3	2
BLOOD_Lymphoma	DMRTB1 →	+0.012	+3.714	.003	.006	3	1
BLOOD_Lymphoma	MEIKIN →	+0.203	+4.169	<.001	.002	3	1
LARGE_INTESTINE	DESI1 →	+0.586	+3.299	<.001	.004	3	1
LARGE_INTESTINE	NISCH →	+0.808	+3.067	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 337 associations by consensus.

GFRAL by PNPLA8 expression — LUNG_SCLC

Explore this box plot interactively →