PNPLA7

Across TCGA patient cohorts, PNPLA7 mutation is significantly associated with the RNA expression of many other genes, with 5,212 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNPLA7-associated genes across cancer lineages are TRAJ47, NANS, and RPS29P32. Each is linked with PNPLA7 in more than 3 cancer types. Because this analysis shows association rather than direction, both PNPLA7-to-partner and partner-to-PNPLA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ47 grouped by PNPLA7-low versus PNPLA7-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA7→partner) and Y-score (partner→PNPLA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	TRAJ47 →	+0.407	+4.007	<.001	<.001	3	4
COAD	NANS →	+0.524	+3.361	<.001	.004	3	4
UCEC	RPS29P32 →	+0.199	+1.447	.004	.007	3	3
UCEC	GEMIN4 →	+0.414	+2.480	<.001	<.001	3	3
UCEC	KMT5A →	+0.355	+2.544	<.001	<.001	3	3
UCEC	LONP1 →	+0.491	+2.732	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,212 associations by consensus.

TRAJ47 by PNPLA7 expression — BLCA

Explore this box plot interactively →