PNPLA7

Across TCGA cell cohorts, PNPLA7 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,017 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PNPLA7-associated GO terms across cancer lineages are Intracellular sphingolipid homeostasis, Regulation of myoblast fusion, and Pre-mRNA catabolic process. Each is linked with PNPLA7 in more than 12 cancer types. Because this analysis shows association rather than direction, both PNPLA7-to-partner and partner-to-PNPLA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intracellular sphingolipid homeostasis grouped by PNPLA7-low versus PNPLA7-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA7→partner) and Y-score (partner→PNPLA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Intracellular sphingolipid homeostasis →	+0.126	+1.491	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.118	+0.832	<.001	.001	3	13
BONE	Pre-mRNA catabolic process →	+0.165	+0.537	.009	<.001	3	13
LUNG_NSCLC_LUAD	Calcium-independent cell-matrix adhesion →	+0.136	+0.452	<.001	.005	3	13
KIDNEY	Regulation of TOR signaling →	+0.056	+0.917	<.001	.001	3	12
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.170	+0.813	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,017 associations by consensus.

Intracellular sphingolipid homeostasis by PNPLA7 expression — BREAST

Explore this box plot interactively →