PNPLA5

Across TCGA patient cohorts, PNPLA5 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNPLA5-associated genes across cancer lineages are PKC-delta_pS664, Smad3, and eEF2. Each is linked with PNPLA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PNPLA5-to-partner and partner-to-PNPLA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-delta_pS664 grouped by PNPLA5-low versus PNPLA5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA5→partner) and Y-score (partner→PNPLA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-delta_pS664 →	-0.108	-2.999	.039	.035	3	2
UCEC	Smad3 →	+0.156	+2.321	.018	.034	3	2
UCEC	eEF2 →	+0.386	+3.321	.013	.010	3	1
UCEC	EGFR_pY1068 →	-0.370	-2.807	<.001	.003	3	1
UCEC	eIF4E →	+0.192	+3.013	.036	.018	3	1
UCEC	ERK2 →	+0.226	+3.169	.007	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

PKC-delta_pS664 by PNPLA5 expression — UCEC

Explore this box plot interactively →