PNPLA5

Across TCGA pan-cancer cohorts, PNPLA5 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated PNPLA5 data layer compared with 7 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher PNPLA5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PNPLA5 expression acts as an unfavorable survival marker, although some lineages such as BLCA and THCA show a favorable association.

THYM, UCEC, and KIRC are the cancer types where PNPLA5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	DFS	Median	II,III,IV	0.526	0.892	<.001	80	view →
UCEC	OS	Median	All	0.576	0.785	<.001	74	view →
KIRC	DFS	Median	All	0.495	0.701	<.001	74	view →
OV	OS	Median	All	0.794	0.885	.002	50	view →
LUAD	OS	Quartile	All	0.740	0.846	.008	32	view →
COAD	OS	Tertile	IV	0.064	0.678	<.001	27	view →
BLCA	OS	Tertile	All	0.815	0.622	.028	14	view →
MESO	OS	Tertile	III,IV	0.422	0.609	.021	12	view →
CHOL	DFS	Tertile	III,IV	0.163	0.529	.024	9	view →
THCA	DFS	Median	III,IV	0.972	0.870	.010	6	view →
PRAD	DFS	Tertile	All	0.956	0.925	.047	4	view →
LUSC	DFS	Tertile	All	0.333	0.453	.030	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

PNPLA5–THYM (DFS)

Open the THYM breakdown →