PNPLA5

Across TCGA cell cohorts, PNPLA5 RNA expression is significantly associated with the go_rna of many other GO terms, with 405 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible PNPLA5-associated GO terms across cancer lineages are Mitochondrion organization, Response to BMP, and Cellular response to BMP stimulus. Each is linked with PNPLA5 in more than 3 cancer types. Because this analysis shows association rather than direction, both PNPLA5-to-partner and partner-to-PNPLA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrion organization grouped by PNPLA5-low versus PNPLA5-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA5→partner) and Y-score (partner→PNPLA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Mitochondrion organization →	+0.042	+0.511	.003	.002	3	4
LUNG_SCLC	Response to BMP →	-0.048	-0.711	<.001	.001	3	4
LUNG_SCLC	Cellular response to BMP stimulus →	-0.048	-0.711	<.001	.001	3	4
LUNG_NSCLC_LUSC	Nucleoside triphosphate biosynthetic process →	+0.066	+0.338	.003	.005	3	4
OESOPHAGUS	Ribose phosphate biosynthetic process →	+0.078	+0.440	.001	.009	3	4
OESOPHAGUS	Ribonucleotide biosynthetic process →	+0.083	+0.512	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 405 associations by consensus.

Mitochondrion organization by PNPLA5 expression — LUNG_SCLC

Explore this box plot interactively →