PNPLA5

Across TCGA cell cohorts, PNPLA5 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PNPLA5-associated genes across cancer lineages are SLC6A19, TAFA1, and NAT8B. Each is linked with PNPLA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PNPLA5-to-partner and partner-to-PNPLA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC6A19 grouped by PNPLA5-low versus PNPLA5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA5→partner) and Y-score (partner→PNPLA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC6A19 →	+1.626	+3.415	<.001	.004	3	1
LARGE_INTESTINE	TAFA1 →	+0.205	+2.688	.004	.008	3	1
LARGE_INTESTINE	NAT8B →	+0.614	+3.667	.007	.003	3	1
LARGE_INTESTINE	LRRC3C →	+0.252	+3.099	<.001	.004	3	1
LARGE_INTESTINE	NEXMIF →	+0.198	+2.933	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

SLC6A19 by PNPLA5 expression — LARGE_INTESTINE

Explore this box plot interactively →