PNPLA4

Across TCGA patient cohorts, PNPLA4 protein abundance is significantly associated with the RNA expression of many other genes, with 12,117 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PNPLA4-associated genes across cancer lineages are ARSD, SCLT1, and USP9Y. Each is linked with PNPLA4 in more than 4 cancer types. Because this analysis shows association rather than direction, both PNPLA4-to-partner and partner-to-PNPLA4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PNPLA4 versus ARSD in BRCA, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA4→partner) and Y-score (partner→PNPLA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARSD →	+0.952	+0.538	<.001	<.001	3	5
COAD	SCLT1 →	-0.357	-0.577	.009	.003	3	4
LSCC	USP9Y →	-1.399	-0.367	<.001	<.001	3	3
COAD	PUDP →	+0.945	+0.699	<.001	<.001	3	3
COAD	ABRAXAS2 →	-0.350	-0.803	<.001	<.001	3	3
LSCC	UTY →	-1.595	-0.380	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,117 associations by consensus.

PNPLA4 vs ARSD — BRCA

Explore this scatter interactively →