PNPLA4

Across TCGA cell cohorts, PNPLA4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,116 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PNPLA4-associated GO terms across cancer lineages are Cellular response to oxidative stress, Monocarboxylic acid catabolic process, and Energy derivation by oxidation of organic compounds. Each is linked with PNPLA4 in more than 7 cancer types. Because this analysis shows association rather than direction, both PNPLA4-to-partner and partner-to-PNPLA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to oxidative stress grouped by PNPLA4-low versus PNPLA4-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA4→partner) and Y-score (partner→PNPLA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Cellular response to oxidative stress →	+0.040	+0.989	.003	.006	3	8
LUNG_SCLC	Monocarboxylic acid catabolic process →	+0.046	+1.581	.005	.002	3	7
PANCREAS	Energy derivation by oxidation of organic compounds →	+0.055	+1.077	<.001	.001	3	7
BREAST	Nucleoside phosphate biosynthetic process →	+0.031	+0.837	.001	.008	3	7
PANCREAS	Oxidative phosphorylation →	+0.076	+1.055	<.001	<.001	3	7
SKIN	Cellular pigmentation →	+0.060	+0.853	.005	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,116 associations by consensus.

Cellular response to oxidative stress by PNPLA4 expression — PANCREAS

Explore this box plot interactively →