PNPLA2

Across TCGA patient cohorts, PNPLA2 mutation is significantly associated with the RNA expression of many other genes, with 492 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNPLA2-associated genes across cancer lineages are TRAJ21, RNU6-362P, and PUDPP1. Each is linked with PNPLA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PNPLA2-to-partner and partner-to-PNPLA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ21 grouped by PNPLA2-low versus PNPLA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA2→partner) and Y-score (partner→PNPLA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAJ21 →	+0.481	+2.477	<.001	.002	3	2
UCEC	RNU6-362P →	+0.083	+4.153	<.001	.005	3	2
COAD	PUDPP1 →	+0.170	+5.357	<.001	.006	3	1
COAD	ATP13A5-AS1 →	+0.175	+5.602	.003	.004	3	1
COAD	IGKV3D-31 →	+0.267	+5.435	<.001	.005	3	1
COAD	MIR4307HG →	+0.091	+6.003	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 492 associations by consensus.

TRAJ21 by PNPLA2 expression — UCEC

Explore this box plot interactively →