PNPLA2

Across TCGA pan-cancer cohorts, PNPLA2 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated PNPLA2 data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher PNPLA2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PNPLA2 expression acts as an unfavorable survival marker, although some lineages such as BRCA and SCLC show a favorable association.

BRCA, LGG, and ACC are the cancer types where PNPLA2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	III,IV	0.910	0.757	<.001	50	view →
LGG	DFS	Median	All	0.653	0.819	<.001	46	view →
ACC	DFS	Tertile	All	0.246	0.735	<.001	44	view →
LUSC	OS	Tertile	All	0.304	0.472	.003	42	view →
SCLC	DFS	Median	II,III,IV	0.833	0.190	<.001	35	view →
HNSC	DFS	Tertile	II,III,IV	0.487	0.298	.003	30	view →
LUAD	DFS	Quartile	II,III,IV	0.552	0.899	<.001	26	view →
ESCA	OS	Quartile	II,III,IV	0.581	0.861	.006	25	view →
SKCM	OS	Quartile	All	0.940	0.848	.007	24	view →
UCS	DFS	Median	III,IV	0.160	0.514	.008	24	view →
DLBC	OS	Median	All	1.000	0.794	.004	20	view →
STAD	DFS	Quartile	IV	0.193	0.718	.016	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

PNPLA2–BRCA (OS)

Open the BRCA breakdown →