PNPLA2

Across TCGA patient cohorts, PNPLA2 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNPLA2-associated genes across cancer lineages are Fibronectin, MSH2, and p90 RSK. Each is linked with PNPLA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PNPLA2-to-partner and partner-to-PNPLA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by PNPLA2-low versus PNPLA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA2→partner) and Y-score (partner→PNPLA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.359	-2.115	.012	.019	3	1
UCEC	MSH2 →	-0.252	-2.973	.012	.035	3	1
UCEC	p90 RSK →	+0.188	+1.598	.025	.044	3	1
UCEC	PDK1_pS241 →	+0.149	+1.598	.045	.044	3	1
UCEC	Rab25 →	-0.396	-2.999	.006	.035	3	1
UCEC	Annexin-1 →	+0.477	+2.999	.038	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Fibronectin by PNPLA2 expression — UCEC

Explore this box plot interactively →