PNPLA2

Across TCGA cell cohorts, PNPLA2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,441 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible PNPLA2-associated GO terms across cancer lineages are Acylglycerol acyl-chain remodeling, Negative regulation of macroautophagy, and Cellular detoxification of methylglyoxal. Each is linked with PNPLA2 in more than 19 cancer types. Because this analysis shows association rather than direction, both PNPLA2-to-partner and partner-to-PNPLA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acylglycerol acyl-chain remodeling grouped by PNPLA2-low versus PNPLA2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA2→partner) and Y-score (partner→PNPLA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Acylglycerol acyl-chain remodeling →	+0.363	+1.017	<.001	<.001	3	20
PANCREAS	Negative regulation of macroautophagy →	+0.072	+1.106	.001	.002	3	16
OESOPHAGUS	Cellular detoxification of methylglyoxal →	+0.201	+1.415	.006	.009	2	17
OESOPHAGUS	Response to methylglyoxal →	+0.201	+1.415	.006	.009	2	17
OESOPHAGUS	Cellular response to methylglyoxal →	+0.201	+1.415	.006	.009	2	17
OESOPHAGUS	Protein localization to plasma membrane →	+0.095	+1.781	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,441 associations by consensus.

Acylglycerol acyl-chain remodeling by PNPLA2 expression — SOFT_TISSUE

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