PNPLA2

Across TCGA cell cohorts, PNPLA2 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PNPLA2-associated genes across cancer lineages are HPCAL4, RAI2, and GSC. Each is linked with PNPLA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PNPLA2-to-partner and partner-to-PNPLA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HPCAL4 grouped by PNPLA2-low versus PNPLA2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA2→partner) and Y-score (partner→PNPLA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HPCAL4 →	+0.211	+3.700	<.001	.002	3	1
BLOOD_Leukemia	RAI2 →	+0.064	+3.165	.008	.001	3	1
BLOOD_Leukemia	GSC →	+0.874	+3.211	<.001	.002	3	1
BLOOD_Leukemia	PCDH19 →	+0.160	+3.415	.005	.004	3	1
BLOOD_Leukemia	CHST1 →	+0.523	+3.481	<.001	.006	3	1
BLOOD_Leukemia	CYP4A11 →	+0.022	+3.857	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

HPCAL4 by PNPLA2 expression — BLOOD_Leukemia

Explore this box plot interactively →