PNPLA1

Across TCGA pan-cancer cohorts, PNPLA1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PNPLA1 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in sarcoma (SARC), where higher PNPLA1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PNPLA1 expression acts as an unfavorable survival marker.

SARC and LIHC are the cancer types where PNPLA1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
LIHC	OS	Median	All	0.098	0.774	.001	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

PNPLA1–SARC (DFS)

Open the SARC breakdown →